Many components that are considered fracture critical require complete inspection utilizing test methods such as computed tomography (CT). The question that often follows is how can we have confidence in this test method when it comes to defect detectability? This presentation will take a detailed look at the qualification process for a CT system, and how that process can give confidence to quality inspection for critical components in the aerospace industry. The first step requires the test method to validate detectability against a known defect standard known as a Representative Quality Indicator (RQI). To have a known part with relevant indications located throughout the test piece will always be the best method, but the availability of such a test piece is not always the reality. An alternative to this validation process is to establish an STL file of the part with relevant indications imbedded into the file. This STL can then be used in digital twin software with a proposed CT technique to create a 3-D rendering of simulated data. Once reconstructed the data can be processed to analyze embedded digital defects for determination of detectability. Detectability as it relates to computed tomography data can be broken down to resolution, unsharpness, contrast, and noise. The balance of these test parameters can be validated with the simulated data with surprising real-world accuracy. After the technique and process are established there needs to be continuous monitoring of the system to verify nothing has changed since technique validation. This process is established in ASTM standard E1695. This standard looks at Modulation Transfer Function (MTF) and Contrast Discrimination Function (CDF) which monitors the main components of detectability discussed earlier. This testing looks at the major components of the CT system for output and alignment. Those components consist of the x-ray tube, manipulator, and digital detector array (DDA). This type of testing needs to be completed at a minimum weekly but may be completed daily depending on the components under test. As a final component of the process there is also a need for validation of review stations for inspection along with the qualifications and certifications of those performing those inspections. Combining the above processes helps establish repeatability and confidence in testing which is critical in quality evaluation in industry.